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(+)-Pagoclone
- CI 1043
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C23H22ClN3O2
- MW: 407.89
Description
(+)-Pagoclone (CI-1043) is a subtype-selective partial agonist at GABAA receptors with preferential activity at α2/α3-containing receptor subtypes.
α2/α3 GABAA receptor modulation is associated with anxiolytic effects, while α1 activity is more closely linked to sedation. (+)-Pagoclone is useful for studying subtype-selective benzodiazepine-site pharmacology and separating anxiolytic from sedative mechanisms.
Key Features
- Subtype-selective GABAA receptor partial agonist
- Preferential pharmacology at α2/α3-containing receptors
- Modulates the benzodiazepine recognition site
- Useful for anxiolytic versus sedative mechanism studies
Applications
- GABAA receptor subtype pharmacology
- Anxiety model research
- Benzodiazepine-site binding and functional assays
- CNS safety and sedation profiling
More Information
| Parent CAS No. | 133737-32-3 |
|---|---|
| Chemical Name | 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one |
| SMILES | C1C=C2C(=O)N(C3N=C4N=C(Cl)C=CC4=CC=3)C(CC(CCC(C)C)=O)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3 |
| InChiKey | HIUPRQPBWVEQJJ-UHFFFAOYSA-N |
| CID | 131664 |
| Short Description | GABAA α2/α3 agonist |
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