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NS 11394
- Soluble in DMSO
- MF: C23H19N3O
- MW: 353.42
Description
NS 11394 is a subtype-selective GABAA receptor positive allosteric modulator with a functional preference profile of α5 > α3 > α2 > α1-containing receptors.
NS 11394 potentiates GABA-mediated chloride currents while maintaining relatively low efficacy at α1-containing receptors. This profile supports studies of analgesia, anxiety, cognition and the contribution of distinct GABAA α-subunits to efficacy and side effects.
Key Features
- Subtype-selective GABAA receptor PAM
- Functional preference: α5 > α3 > α2 > α1
- Higher efficacy at α3 than α1-containing receptors
- Useful for separating therapeutic and sedative GABAA effects
Applications
- GABAA receptor subtype profiling
- Pain and analgesia models
- Anxiety and inhibitory-neurotransmission studies
- Memory, motor and sedation-response research
More Information
| Parent CAS No. | 951650-22-9 |
|---|---|
| Chemical Name | 3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile |
| SMILES | C1(C(C)(C)O)C=C2N=CN(C3C=C(C4C(C#N)=CC=CC=4)C=CC=3)C2=CC=1 |
| MFCD | MFCD12912405 |
| InChi | InChI=1S/C23H19N3O/c1-23(2,27)18-10-11-22-21(13-18)25-15-26(22)19-8-5-7-16(12-19)20-9-4-3-6-17(20)14-24/h3-13,15,27H,1-2H3 |
| InChiKey | HLKYSQGBIIIQJN-UHFFFAOYSA-N |
| CID | 16747643 |
| Short Description | GABAA PAM |
References
- NR Mirza et al. NS11394 , a Unique Subtype-Selective GABAA Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic Properties and in Vivo Anxiolytic Efficacy. J. Pharmacol. Exp. Ther. 2008, 327, 954-968.
- G. Munro et al. Comparison of the Novel Subtype-Selective GABAA Receptor-Positive Allosteric Modulator NS11394 with Diazepam, Zolpidem, Bretazenil, and Gaboxadol in Rat Models of Inflammatory and Neuropathic Pain. J. Ph. Exp. Ther. 2008, 327, 969-981.
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