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AZD7325
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C19H19FN4O2
- MW: 354.38
Description
AZD7325 is a potent, selective GABAA-α2 and GABAA-α3 modulator intended for the treatment of anxiety (pKi value of 9.51 for GABAA-α2).
More Information
| Parent CAS No. | 942437-37-8 |
|---|---|
| Chemical Name | 4-Amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide |
| SMILES | C1(OC)C(C2C=CC=C3C(N)=C(C(NCCC)=O)N=NC=23)=C(F)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25) |
| InChiKey | KYDURMHFWXCKMW-UHFFFAOYSA-N |
| CID | 23581869 |
| Short Description | GABAA α2/α3 agonist |
References
- C Alhambra et al. Development and SAR of functionally selective allosteric modulators of GABAA receptors. Bioorg Med Chem. 2011 May 1;19(9):2927-38.
- D Zhou et al. A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison. Br J Clin Pharmacol. 2012 Jul;74(1):98-108.
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