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Gabapentin
- GOE 3450 - CI 945 - GO 3450
- Soluble in water
- MF: C9H17NO2
- MW: 171.24
Description
Gabapentin is an anticonvulsant and neuropathic pain research compound that binds the α2δ subunit of voltage-gated calcium channels rather than directly activating GABA receptors.
Gabapentin modulates excitatory neurotransmitter release and neuronal excitability through α2δ-associated calcium channel mechanisms. It is used to study seizure-related pathways, neuropathic pain signaling and synaptic transmission.
Key Features
- Ligand of the α2δ calcium channel subunit
- Modulates neuronal excitability and neurotransmitter release
- Anticonvulsant pharmacology profile
- Useful for neuropathic pain and seizure pathway research
Applications
- α2δ calcium channel studies
- Neuropathic pain model research
- Anticonvulsant mechanism studies
- Neuronal excitability and synaptic transmission assays
More Information
| Parent CAS No. | 60142-96-3 |
|---|---|
| Chemical Name | (1-Aminomethyl-cyclohexyl)-acetic acid |
| SMILES | C1C(CC(O)=O)(CN)CCCC1 |
| MFCD | MFCD00865286 |
| InChi | InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12) |
| InChiKey | UGJMXCAKCUNAIE-UHFFFAOYSA-N |
| CID | 3446 |
| Short Description | GABA modulator |
References
- G de Sarro et al. Gabapentin potentiates the antiseizure activity of certain anticonvulsants in DBA/2 mice. Eur. J. Pharmacol. 1998, 349, 179-185.
- MJ Field et al. Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br. J. Pharmacol. 1997, 121, 1513-1522.
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