Bulk Inquiry
PK 11195
- No solubility data
- MF: C21H21ClN2O
- MW: 352.86
Description
PK 11195 is a high-affinity ligand of the translocator protein 18 kDa (TSPO), historically known as the peripheral benzodiazepine receptor.
TSPO is localized mainly to the outer mitochondrial membrane and is widely used as a marker and pharmacological target in neuroinflammation, glial activation and mitochondrial function studies. PK 11195 remains a key reference compound for TSPO binding assays and imaging-related research.
Key Features
- High-affinity TSPO/PBR ligand
- Reference compound for peripheral benzodiazepine receptor studies
- Relevant to mitochondrial and neuroinflammation pharmacology
- Useful comparator for TSPO imaging ligand development
Applications
- TSPO binding and displacement assays
- Neuroinflammation and microglial activation studies
- Mitochondrial pharmacology research
- Radioligand and PET tracer precursor workflows
Related Axon Medchem products include the active isomer (R)-(-)-PK 11195 (Axon 2785), N-Desmethyl-PK 11195 (Axon 2833) and (R)-(-)-N-Desmethyl-PK 11195 (Axon 2784).
More Information
| Parent CAS No. | 85532-75-8 |
|---|---|
| Chemical Name | 1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic acid sec-butyl-methyl-amide |
| SMILES | C1C=C2C=C(C(=O)N(C)C(C)CC)N=C(C3C(Cl)=CC=CC=3)C2=CC=1 |
| MFCD | MFCD00069334 |
| InChi | InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 |
| InChiKey | RAVIZVQZGXBOQO-UHFFFAOYSA-N |
| CID | 1345 |
| Short Description | BZD antagonist |
References
- A Klegeris et al. Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK 11195) on some mononuclear phagocyte functions. Biochem. Pharmacol. 2000, 59, 1305-1314.
- EP Wala et al. Pharmacokinetics of the peripheral benzodiazepine receptor antagonist, PK 11195, in rats. The effect of dose and gender. Pharmacol. Res. 2000, 41, 461-468.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1121 | NBI 34060 |
From $110.00 |
| 1195 | SL 651498 |
From $88.00 |
| 1196 | L 838417 |
From $132.00 |
| 1197 | Zopiclone |
From $77.00 |
| 1301 | Gabapentin |
From $71.50 |
| 1422 | TP003 |
From $88.00 |
| 1457 | NS 11394 |
From $121.00 |
| 1594 | (+)-Pagoclone |
From $148.50 |
| 1604 | CP 615003 mesylate |
From $99.00 |
| 1646 | Zaleplon |
From $77.00 |
| 1820 | GS 39783 |
From $99.00 |
| 2784 | (R)-(-)-N-Desmethyl-PK 11195 |
From $176.00 |
| 2785 | (R)-(-)-PK 11195 |
From $143.00 |
| 3042 | AZD6280 |
From $137.50 |
| 3087 | AZD7325 |
From $99.00 |
| 3119 | Stiripentol |
From $88.00 |
| 3331 | Etifoxine hydrochloride |
From $121.00 |
| 3388 | Etifoxine |
From $99.00 |
| 3390 | L-655,708 |
From $132.00 |
| 3406 | Demoxepam |
From $132.00 |
| 3698 | AC-5216 |
From $99.00 |
