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Sunepitron hydrochloride
- CP 93393 hydrochloride - CP 93393-1
- Parent CAS: 131831-03-3
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C17H23N5O2.HCl
- MW: 365.86
Description
Sunepitron hydrochloride is a multimodal CNS ligand reported to act as a serotonin 5-HT1A autoreceptor agonist, alpha-2 adrenergic antagonist and dopamine D2 receptor agonist.
Combined serotonergic, adrenergic and dopaminergic pharmacology is relevant to the regulation of mood, anxiety and monoamine neurotransmission. Sunepitron can be applied in CNS receptor-profiling studies and models that assess interactions among monoamine systems. Sunepitron hydrochloride is the preferred water-soluble salt form.
Key Features
- Multimodal monoaminergic receptor ligand
- 5-HT1A autoreceptor agonist activity
- Alpha-2 adrenergic antagonist activity
- Dopamine D2 receptor agonist component
Applications
- Anxiolytic and antidepressant mechanism research
- Monoamine neurotransmission studies
- 5-HT1A and alpha-2 receptor pharmacology
- CNS receptor interaction assays
More Information
| Parent CAS No. | 131831-03-3 |
|---|---|
| Chemical Name | 1-(((7S,9aS)-2-(pyrimidin-2-yl)octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methyl)pyrrolidine-2,5-dione hydrochloride |
| extra_info | . |
| SMILES | C1C[C@H]2CN(C3N=CC=CN=3)CCN2C[C@H]1CN1C(=O)CCC1=O.Cl |&1:2,15,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H23N5O2.ClH/c23-15-4-5-16(24)22(15)11-13-2-3-14-12-21(9-8-20(14)10-13)17-18-6-1-7-19-17;/h1,6-7,13-14H,2-5,8-12H2;1H/t13-,14-;/m0./s1 |
| InChiKey | HWGPYTRJVVMHGT-IODNYQNNSA-N |
| CID | 6918176 |
| Short Description | 5-HT1A, α2, and D2 ligand; Anxiolytic |
References
- S.T. Colgan et al. Assay and purity evaluation of sunepitron hydrochloride by reversed-phase liquid chromatography using a reference standard composite. J Pharm Biomed Anal. 1998 Nov;18(3):429-40.
- J. Silvestre et al. Sunepitron Hydrochloride. Drugs Fut. 1998; 23(2):161-165.
- C. Prakash et al. Metabolism and excretion of a novel antianxiety drug candidate, CP-93,393, in Long Evans rats. Differentiation of regioisomeric glucuronides by LC/MS/MS. Drug Metab Dispos. 1997 Nov;25(11):1288-97.
- C. Prakash et al. Metabolism and excretion of a new anxiolytic drug candidate, CP-93, 393, in healthy male volunteers. Drug Metab Dispos. 1998 May;26(5):448-56.
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