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Guanfacine hydrochloride
- BS100-141
- Parent CAS: 29110-47-2
- Soluble in water and DMSO
- MF: C9H9Cl2N3O.HCl
- MW: 282.55
Description
Guanfacine hydrochloride is a selective α2-adrenergic receptor agonist with a Kd value of 31 nM. Centrally acting antihypertensive agent.
More Information
| Parent CAS No. | 29110-47-2 |
|---|---|
| Chemical Name | N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride |
| SMILES | Cl.C1C(Cl)=C(CC(NC(N)=N)=O)C(Cl)=CC=1 |
| MFCD | MFCD00798230 |
| InChi | InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H |
| InChiKey | DGFYECXYGUIODH-UHFFFAOYSA-N |
| CID | 71401 |
| Short Description | α2 agonist |
References
- PA van Zwieten. Pharmacology of centrally acting hypotensive drugs. Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):13S-20S.
- S Uhlén et al. Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound. Eur J Pharmacol. 1991 Sep 17;202(2):235-43.
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