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Atipamezole hydrochloride
- Antisedan - MPV 1248
- Parent CAS: 104054-27-5
- Soluble in water
- MF: C14H16N2.HCl
- MW: 248.75
Description
Atipamezole hydrochloride is a potent and competitive α2-adrenoceptor antagonist with a reported Ki value of 1.6 nM.
By blocking presynaptic and postsynaptic α2-adrenergic signaling, atipamezole reverses the pharmacological effects of α2 agonists such as medetomidine, xylazine and detomidine. It is a standard tool for adrenergic receptor pharmacology and reversal studies.
Key Features
- High-affinity competitive α2-adrenoceptor antagonist
- Reported Ki: 1.6 nM
- Reverses α2-agonist-mediated sedation and sympatholysis
- Useful for presynaptic noradrenergic feedback studies
Applications
- α2-adrenoceptor binding and functional assays
- Reversal of medetomidine, xylazine and detomidine responses
- Noradrenergic neurotransmission research
- Autonomic and sedative pharmacology models
More Information
| Parent CAS No. | 104054-27-5 |
|---|---|
| Chemical Name | 5-(2-Ethyl-indan-2-yl)-1H-imidazole hydrochloride |
| SMILES | C1C=C2CC(C3NC=NC=3)(CC)CC2=CC=1.Cl |
| MFCD | MFCD06407819 |
| InChi | InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H |
| InChiKey | PCCVCJAQMHDWJY-UHFFFAOYSA-N |
| CID | 13649426 |
| Short Description | α2 antagonist |
References
- R Virtanen et al. Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole. Arch. Int. Pharmacodyn. Ther. 1989, 297 190-204.
- K Puurunen et al. An α2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacol. 2001, 40, 597-606.
- A Pertovaara et al. Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist. CNS Drug Rev. 2005 Autumn;11(3):273-88.
- CW Jurgens et al. Alpha2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol Pharmacol. 2007, 71(6), 1572-1581.
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