Bulk Inquiry
TAK 259
- Parent CAS: 1192348-73-4
- Soluble in water and DMSO
- MF: C14H13Cl2N3O3S.HCl
- MW: 410.7
Description
Novel, selective, and orally active α1D adrenoceptor antagonist (Ki value 1.1 nM, and 200-800 fold selective over α1A and α1B, respectively) with anti-urinary frequency effects: reducing human Ether-a-go-go-Related Gene (hERG) liabilities. Clinical candidate, and a promising novel therapeutic agent for the treatment of OAB (overactive bladder) symptoms.
More Information
| Parent CAS No. | 1192348-73-4 |
|---|---|
| Chemical Name | 5-chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride |
| SMILES | C1(=N)N(CC2=CC(Cl)=CC=C2S(C)(=O)=O)C=C(Cl)C=C1C(N)=O.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C14H13Cl2N3O3S.ClH/c1-23(21,22)12-3-2-9(15)4-8(12)6-19-7-10(16)5-11(13(19)17)14(18)20;/h2-5,7,17H,6H2,1H3,(H2,18,20);1H |
| InChiKey | MWQYDDZQXFWUAN-UHFFFAOYSA-N |
| CID | 66970086 |
| Short Description | α1D antagonist |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1154 | B-HT 933 dihydrochloride |
From $132.00 |
| 1155 | Efaroxan hydrochloride |
From $71.50 |
| 1290 | ST 91 |
From $88.00 |
| 1296 | Modafinil |
From $66.00 |
| 1371 | Atipamezole hydrochloride |
From $104.50 |
| 1555 | Brimonidine tartrate |
From $77.00 |
| 1750 | MIBG hemisulfate |
From $126.50 |
| 2040 | Prazosin hydrochloride |
From $55.00 |
| 3112 | Silodosin |
From $66.00 |
| 3456 | Carvedilol |
From $55.00 |
| 3512 | Terazosin hydrochloride |
From $66.00 |
| 3643 | Phenoxybenzamine hydrochloride |
From $55.00 |
