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Carvedilol
- BM14190
- Soluble in DMSO and EtOH
- MF: C24H26N2O4
- MW: 406.47
Description
Carvedilol is a β-adrenoceptor antagonist which also causes peripheral vasodilation primarily via α1-adrenergic blockade (Ki values of 0.81, 0.96 and 2.2 nM for β1-, β2-, and α1-adrenoceptors, respectively). Carvedilol produces its antihypertensive effect partly by reducing total peripheral resistance by blocking α1-adrenoceptors and by preventing β-adrenoceptor-mediated compensatory mechanisms.
More Information
| Parent CAS No. | 72956-09-3 |
|---|---|
| Chemical Name | 1-(9H-Carbazol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol |
| SMILES | C12C(OCC(O)CNCCOC3C=CC=CC=3OC)=CC=CC=1NC1C=CC=CC2=1 |
| MFCD | MFCD00864692 |
| InChi | InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3 |
| InChiKey | OGHNVEJMJSYVRP-UHFFFAOYSA-N |
| CID | 2585 |
| Short Description | β/α1 antagonist |
References
- K Pönicke et al. Differential effects of bucindolol and carvedilol on noradenaline-induced hypertrophic response in ventricular cardiomyocytes of adult rats. J Pharmacol Exp Ther. 2002 Apr;301(1):71-6.
- D McTavish et al. Carvedilol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1993 Feb;45(2):232-58.
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