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GW 803430
- GW 3430
Axon 1569
CAS:
515141-51-2
Purity:
99%
- Soluble in DMSO
- MF: C25H24ClN3O3S
- MW: 481.99
Description
GW 803430 is a selective, non-peptide antagonist of the melanin-concentrating hormone receptor 1 (MCHR1).
MCHR1 signaling is implicated in energy balance, feeding behavior, stress responses and affective regulation. GW 803430 is useful for studying MCH receptor blockade in metabolic, anxiolytic and antidepressant-like preclinical models.
Key Features
- Selective non-peptide MCHR1 antagonist
- Blocks melanin-concentrating hormone receptor signaling
- Pharmacology relevant to feeding and energy-balance pathways
- Reported anxiolytic- and antidepressant-like effects in animal studies
Applications
- MCHR1 receptor pharmacology
- Obesity and feeding behavior research
- Anxiety and depression model studies
- Neuropeptide GPCR antagonist assays
More Information
| Parent CAS No. | 515141-51-2 |
|---|---|
| Chemical Name | 6-(4-Chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one |
| SMILES | C1(=CC2N=CN(C3C=CC(OCCN4CCCC4)=C(OC)C=3)C(=O)C=2S1)C1C=CC(Cl)=CC=1 |
| MFCD | MFCD09970889 |
| InChi | InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 |
| InChiKey | MWULMTACIBZPGN-UHFFFAOYSA-N |
| CID | 9826520 |
| Short Description | MCH1 antagonist |
References
- DR Gehlert et al. Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J. Pharmacol. Exp. Ther. 2009, 329 (2), 429–438.
- SL Able et al. Localisation of melanin-concentrating hormone receptor 1 in rat brain and evidence that sleep parameters are not altered despite high central receptor occupancy. Eur. J. Pharmacol. 2009, 616(1-3), 101-106.
- S Chaki and K Kanuma. Neuropeptide receptors: Novel therapeutic targets for depression and anxiety disorders. Drugs Fut. 2007, 32(9), 809.
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