Melanin concentrating hormone (MCH) is an orexigenic cyclic nonadeca-peptide, predominantly expressed in the lateral hypothalamus and zona incerta, acting at the G-protein coupled receptors (GPCR subfamily A5) MCHR1 and MCHR2 widely expressed in the brain. MCH is an important mediator of energy homeostasis, stimulating food intake in rats after intra cerebro-ventricular (icv) injection, and increasing body weight. Additionally, an emerging body of literature supports a role for MCH and MCHR1 in the endocrine and behavioral responses to stress, suggesting that drugs interacting at this receptor might have an antidepressant and/or anxiolyic effect.
 Melanin concentrating hormone receptor 1 (MCHR1) antagonists—Still a viable approach for obesity treatment? T. Högberg, T.M. Frimurerb, P.K. Sasmalc. Bioorg. Med.Chem.Lett. 2012, 22, 6039-6047
 Preclinical Evaluation of Melanin-Concentrating Hormone Receptor 1 Antagonism for the Treatment of Obesity and Depression. D.R. Gehlert, et al. J.Pharm.Exp.Ther. 2009, 329, 429-438