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Buspirone hydrochloride
- Buspar
Axon 1995
- Parent CAS: 36505-84-7
Purity:
100%
- Soluble in water and DMSO
- MF: C21H31N5O2.HCl
- MW: 421.96
Description
Buspirone hydrochloride is a serotonin 5-HT1A receptor partial agonist with anxiolytic pharmacology. It also interacts with dopaminergic systems, making it useful for studying serotonergic modulation of anxiety-related circuits.
5-HT1A receptors regulate mood, anxiety, serotonergic neuronal firing and stress responses. Buspirone is pharmacologically relevant for CNS receptor studies, anxiolytic mechanism research and models of serotonin-dopamine pathway interaction.
Key Features
- 5-HT1A receptor partial agonist
- Anxiolytic CNS pharmacology
- Modulates serotonergic signaling pathways
- Useful for serotonin-dopamine interaction studies
Applications
- 5-HT1A receptor assays
- Anxiety and stress-response models
- Serotonergic neurotransmission studies
- CNS drug-response profiling
More Information
| Parent CAS No. | 36505-84-7 |
|---|---|
| Chemical Name | 8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride |
| SMILES | C1C2(CC(=O)N(CCCCN3CCN(C4=NC=CC=N4)CC3)C(=O)C2)CCC1.Cl |
| MFCD | MFCD00078569 |
| InChi | InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H |
| InChiKey | RICLFGYGYQXUFH-UHFFFAOYSA-N |
| CID | 36431 |
| Short Description | 5-HT1A agonist |
Buspirone hydrochloride
5-HT1A receptor partial agonist
Buspar
HTR1A
5-HT1A receptor
5-HT1A
Partial agonist
Agonist
dopamine signaling
serotonin signaling
5-HT1A receptor assays
Anxiety and stress-response models
Serotonergic neurotransmission studies
CNS drug-response profiling
neuroscience
anxiety research
signal transduction
receptor pharmacology
CNS
CAS 36505-84-7
CAS 33386-08-2
Axon Medchem
Axon 1995
Supplier
Vendor
References
- DA Ciraulo et al. Alterations in pharmacodynamics of anxiolytics in abstinent alcoholic men: Subjective responses, abuse liability, and electroencephalographic effects of alprazolam, diazepam, and buspirone. J. Clin. Pharmacol. 1997, 37(1), 64-73.
- N Demartinis et al. Prior benzodiazepine use and buspirone response in the treatment of generalized anxiety disorder. J. Clin. Psychiatry 2000, 61(2), 91-94.
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