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TMU4142
- Optical Purity: 99% e.e.
- Soluble in DMSO and EtOH
- MF: C23H31N3O4
- MW: 413.51
Description
TMU4142 is a potent, pathway-selective 5-hydroxytryptamine 1A (5-HT1A) receptor agonist that preferentially activates GoA signaling while minimizing activation of the Gi3 pathway. This biased signaling profile enables selective modulation of 5-HT1A receptor-mediated responses and distinguishes TMU4142 from conventional 5-HT1A agonists.
The 5-HT1A receptor is a G protein-coupled receptor (GPCR) that regulates mood, anxiety, stress responses, and emotional behavior. Biased agonism at GPCRs has emerged as an important strategy for separating therapeutic efficacy from undesirable signaling pathways. TMU4142 demonstrated rapid antidepressant-like effects in mouse models of depression, making it a valuable chemical probe for investigating biased GPCR signaling, serotonin receptor pharmacology, and next-generation antidepressant mechanisms.
Key Features
- Potent pathway-selective 5-HT1A receptor agonist
- Preferential activation of GoA signaling
- Minimizes Gi3 pathway activation
- Demonstrates rapid antidepressant-like activity in vivo
- Useful tool for biased GPCR signaling research
Applications
- 5-HT1A receptor pharmacology
- Biased GPCR signaling studies
- Depression and antidepressant research
- Serotonergic neurotransmission investigations
- Neuroscience and neuropsychopharmacology research
More Information
| Parent CAS No. | 3133081-88-3 |
|---|---|
| Chemical Name | 8-(3-((S)-2-Hydroxy-3-(4-indolyloxy)propylamino)propyl)-8-aza-7,9-spiro[4.5]decanedione |
| SMILES | C12NC=CC=1C(OC[C@@H](O)CNCCCN1C(=O)CC3(CCCC3)CC1=O)=CC=C2 |&1:8,r| |
| InChi | InChI=1S/C23H31N3O4/c27-17(16-30-20-6-3-5-19-18(20)7-11-25-19)15-24-10-4-12-26-21(28)13-23(14-22(26)29)8-1-2-9-23/h3,5-7,11,17,24-25,27H,1-2,4,8-10,12-16H2/t17-/m0/s1 |
| InChiKey | KVCDXJUCIQSGFP-KRWDZBQOSA-N |
| CID | 177693333 |
| Short Description | 5-HT1A agonist |
