Bulk Inquiry
(R)-(+)-8-Hydroxy-DPAT hydrobromide
- Parent CAS: 80300-09-0
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C16H25NO.HBr
- MW: 328.29
Description
(R)-(+)-8-Hydroxy-DPAT hydrobromide is the more active R-(+)-enantiomer of 8-Hydroxy-DPAT (Axon 1015) and acts as a full 5-HT1A receptor agonist. It is suited for experiments requiring robust activation of 5-HT1A receptor signaling.
The 5-HT1A receptor is a major inhibitory serotonin GPCR involved in neuronal excitability, autoreceptor feedback and mood-related circuits. (R)-(+)-8-Hydroxy-DPAT hydrobromide provides an enantiomerically defined agonist for serotonergic pathway studies.
The less active (S)-(-)-8-Hydroxy-DPAT hydrobromide is available as Axon 1017.
Key Features
- Full 5-HT1A receptor agonist
- More active enantiomer of racemic 8-OH-DPAT
- Enantiomerically defined serotonergic ligand
- Useful for 5-HT1A functional response studies
Applications
- 5-HT1A receptor activation assays
- Serotonin receptor pharmacology
- Autoreceptor and postsynaptic 5-HT1A studies
- Enantiomer-specific GPCR research
More Information
| Parent CAS No. | 80300-09-0 |
|---|---|
| Chemical Name | (R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide |
| SMILES | C1C(O)=C2C[C@H](N(CCC)CCC)CCC2=CC=1.Br |&1:5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1 |
| InChiKey | BATPBOZTBNNDLN-PFEQFJNWSA-N |
| CID | 11957570 |
| Short Description | 5-HT1A agonist |
References
- T Yoshitake and J Kehr. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004, 74, 2865.
- LJ Cornfield et al. Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol. Pharmacol. 1991, 39, 780.
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