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U 92016A
- Parent CAS: 136924-88-4
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C19H25N3.HCl
- MW: 331.88
Description
U 92016A is a selective, orally active serotonin 5-HT1A full agonist with high intrinsic activity.
5-HT1A receptors regulate serotonergic neurotransmission, mood-related circuits, anxiety pathways, thermoregulation and neuroendocrine responses. U 92016A is used to activate 5-HT1A signaling in CNS pharmacology studies.
Key Features
- Selective 5-HT1A full agonist
- High intrinsic activity at 5-HT1A receptors
- Orally active pharmacology profile
- Useful for serotonergic CNS pathway research
Applications
- 5-HT1A receptor functional assays
- Serotonergic neurotransmission studies
- Anxiety and mood pathway models
- GPCR agonist efficacy profiling
More Information
| Parent CAS No. | 136924-88-4 |
|---|---|
| Chemical Name | (R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-2-carbonitrile hydrochloride |
| SMILES | [C@H]1(N(CCC)CCC)CC2C3C=C(C#N)NC=3C=CC=2CC1.Cl |&1:0,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H25N3.ClH/c1-3-9-22(10-4-2)16-7-5-14-6-8-19-18(17(14)12-16)11-15(13-20)21-19;/h6,8,11,16,21H,3-5,7,9-10,12H2,1-2H3;1H/t16-;/m1./s1 |
| InChiKey | XHLKAMFNZKKRFJ-PKLMIRHRSA-N |
| CID | 56972129 |
| Short Description | 5-HT1A agonist |
References
- RB McCall et al. Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J. Pharmacol. Exp. Ther. 1994, 271(2), 875-883.
- AG Romero et al. Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. J. Med. Chem. 1993, 36(15), 2066–2074.
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