Bulk Inquiry
WAY 100635 maleate
- Parent CAS: 162760-96-5
- Soluble in water and DMSO
- MF: C25H34N4O2.C4H4O4
- MW: 538.64
Description
Prototypical 5-HT1A receptor antagonist with D4 agonist activity (Ki values 2.2 nM, 6260 nM, 24 nM, >10,000 nM, 20 nM, 322 nM, and 16 nM for 5-HT1A, 5-HT2A, 5-HT2B, 5-HT7, α1A, α1B, and D4, respectively).
The HCl salt of WAY 100635 is available as well (Axon 1086)
More Information
| Parent CAS No. | 162760-96-5 |
|---|---|
| Chemical Name | Cyclohexanecarboxylic acid {2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-pyridin-2-yl-amide maleate |
| SMILES | C1C=CC(OC)=C(N2CCN(CCN(C(C3CCCCC3)=O)C3N=CC=CC=3)CC2)C=1.C(/C(O)=O)=C/C(O)=O |
| MFCD | MFCD01321056 |
| InChi | InChI=1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChiKey | XIGAHNVCEFUYOV-BTJKTKAUSA-N |
| CID | 11957721 |
| Short Description | 5-HT1A antagonist |
References
- B.R. Chemel et al. WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl). 2006 Oct;188(2):244-51.
- EA Forster et al. A pharmacological profile of the selective silent 5-HT1A receptor antagonist WAY-100635. Eur. J. Pharmacol. 1995, 281, 81-88.
- F. Mangin et al. Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4550-4.
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