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(S)-(-)-8-Hydroxy-DPAT hydrobromide

 - (S)-(-)-8-OH-DPAT
Axon 1017
  • Parent CAS:  80300-10-3
  • Optical Purity:  98% e.e.
  • Soluble in DMSO
  • MF:  C16H25NO.HBr
  • MW:  328.29

Description

(S)-(-)-8-Hydroxy-DPAT hydrobromide is the less active S-(-)-enantiomer of 8-Hydroxy-DPAT (Axon 1015) and is described as a partial 5-HT1A receptor agonist. It is useful for comparing partial versus full 5-HT1A receptor agonism.

Partial agonists at 5-HT1A receptors can produce distinct signaling profiles compared with full agonists. (S)-(-)-8-Hydroxy-DPAT hydrobromide is valuable for stereoselectivity studies and for dissecting efficacy-dependent serotonergic responses.

The more active (R)-(+)-8-Hydroxy-DPAT hydrobromide is available as Axon 1016.

Key Features

  • Partial 5-HT1A receptor agonist
  • Less active enantiomer of racemic 8-OH-DPAT
  • Comparator for R-(+)-8-OH-DPAT full agonism
  • Useful for efficacy and stereochemistry studies

Applications

  • 5-HT1A receptor pharmacology
  • Partial agonism studies
  • Serotonergic GPCR signaling assays
  • Enantiomer comparison experiments

More Information

Parent CAS No. 80300-10-3
Chemical Name (S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide
SMILES C1C(O)=C2C[C@@H](N(CCC)CCC)CCC2=CC=1.Br |&1:5,r|
MFCD N.A.
InChi InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m0./s1
InChiKey BATPBOZTBNNDLN-UQKRIMTDSA-N
CID 10125796
Short Description 5-HT1A agonist

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