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Metoclopramide
Axon 3378
CAS:
364-62-5
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C14H22ClN3O2
- MW: 299.8
Description
Metoclopramide is a stimulant of upper gastrointestinal motility and an antiemetic agent. Effects of metoclopramide are believed to be due to a combination of a relatively weak serotonin 5-HT3 and dopamine D2 receptors antagonism and a serotonin 5-HT4 receptor agonism.
More Information
| Parent CAS No. | 364-62-5 |
|---|---|
| Chemical Name | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide |
| SMILES | C1(Cl)C=C(C(NCCN(CC)CC)=O)C(OC)=CC=1N |
| MFCD | MFCD00211338 |
| InChi | InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19) |
| InChiKey | TTWJBBZEZQICBI-UHFFFAOYSA-N |
| CID | 4168 |
| Short Description | D2/5-HT3 antagonist |
References
- JR DiPalma et al. Metoclopramide: a dopamine receptor antagonist. Am Fam Physician. 1990 Mar;41(3):919-24.
- Y Hirokawa et al. Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist. Chem Pharm Bull (Tokyo). 2002 Jul;50(7):941-59.
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