Potassium channels are a diverse and ubiquitous family of membrane proteins present in both excitable and non-excitable cells. Members of this channel family play critical roles in cellular signaling processes regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume regulation. Over 50 human genes encoding various potassium channels have been cloned during the past decade[1]. Based on the structure of the potassium channels, four main classes can be identified. The basis of all channels consists of four subunits that are clustered to form the ion-permeation pathway across the membrane. Each of the four subunits is build up of two transmembrane helices and a short loop between them. Distinct features characterize the four main classes[2]: inwardly rectifying potassium channels (2TM/P channels), voltage and/or ligand gated ion channels (6TM/P channels), hybrid channels made from the two previously mentioned classes (8TM/2P channels), and dimer channels (4TM/2P channels) made from two repeats of the inwardly rectifying channels, and are often referred to as ‘leakage channels’. Also the hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels belong to the superfamily of voltage-gated K+ (Kv) and cyclic nucleotide-gated (CNG) channels. They are sometimes referred to as “pacemaker channels” because they help to generate rhythmic activity within groups of heart and brain cells.
Axon Medchem offers a variety of potassium channel openers and blockers, including the racemate and optically pure enantiomers of BMS204352 (Axon 1112, Axon 1308, and Axon 1309), modulators of the Maxi-K channel (or BK channel, member of 6TM/P channel class), and Zatebradine HCl (Axon 1248, HCN channel blocker).

[1] Potassium Channels: Molecular Defects, Diseases, and Therapeutic Opportunities. C.C. Shieh, M. Coghlan, J.P. Sullivan, M. Gopalakrishnan. Pharmacological Reviews, 2000, 52, 557-594.
[2]  Ion conduction pore is conserved among potassium channels. Lu, Z., Klem, A. M. & Ramu, Y. Nature 2001, 413, 809–813.

24 Item(s)

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Axon ID Name Description From price
2979 ASP 2905 Potent, selective and orally active KCNH3 (Kv12.2) inhibitor €125.00
2243 AVE 0118 hydrochloride Potassium channel blocker (Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents) €120.00
1294 Chromanol 293B KCNQ1 channel blocker €120.00
1322 DMP 543 K+ channel blocker; Ach release stimulator €90.00
2103 Dofetilide Kv11.1 (hERG) channel blocker €85.00
3450 Dronedarone hydrochloride Ca2+/K+/Na+ channel blocker; Antiarrhythmic agent €100.00
1437 Flupirtine maleate Analgesic €65.00
2724 ICA-069673 KCNQ2/KCNQ3 channel opener; Anti-convulsant €90.00
3091 ICA-110381 KCNQ2/KCNQ3 channel opener; Anti-convulsant €80.00
3495 Ivabradine hydrochloride Selective sinus node I(f) channel inhibitor €50.00
1735 Kv1.3 Channel blocker 42 Kv1.3 potassium channel blocker €110.00
3032 LUF7244 Potent negative allosteric modulator (NAM) of the Kv11.1 (hERG) channel €140.00
2747 ML 213 KCNQ2/KCNQ4 channel opener €75.00
2615 ML252 Selective and brain penetrant KCNQ2 inhibitor €95.00
3196 ML277 Potent and selective KCNQ1 channel activator €80.00
3644 Propafenone hydrochloride Ca2+/K+/Na+ channel blocker; Antiarrhythmic agent €60.00
3507 Ranolazine Ca2+/K+/Na+ channel blocker; Anti-anginal agent €70.00
1525 Retigabine KCNQ channel opener; Anti-convulsant €90.00
2252 Retigabine dihydrochloride KCNQ channel opener; Anti-convulsant €90.00
1657 S 9947 Ikur/Kv1.5 channel Inhibitor €125.00
3265 XAF-1407 Potent and highly selective IKACh inhibitor €165.00
1987 XE 991 KCNQ channel and M-current blocker €90.00
1305 XE 991 dihydrochloride KCNQ channel and M-current blocker €90.00
1248 Zatebradine hydrochloride HCN channel blocker €110.00

24 Item(s)

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