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Kv1.3 Channel blocker 42
- Parent CAS: 1201582-43-5
- Soluble in water
- MF: C28H35FN2O4.HCl
- MW: 519.05
Description
Kv1.3 Channel blocker 42 is a selective Kv1.3 potassium channel blocker with an IC50 value below 50 nM for Kv1.3 current inhibition.
Kv1.3 channels regulate membrane potential and Ca2+ signaling in activated T cells and other immune cells. Kv1.3 Channel blocker 42 is useful for studying immunomodulatory ion-channel pharmacology and selectivity versus Kv1.1 and Kv1.5.
Key Features
- Potent blocker of Kv1.3 current
- IC50: <50 nM
- Reported 25-fold selectivity over Kv1.1
- Reported 24-fold selectivity over Kv1.5
Applications
- Kv1.3 channel pharmacology
- T-cell activation and immunology models
- Ion channel selectivity assays
- Autoimmune pathway research
More Information
| Parent CAS No. | 1201582-43-5 |
|---|---|
| Chemical Name | 1-(7-(3-(4-fluorophenyl)butoxy)-2,4-dimethyl-6-(2-(piperidin-1-yl)ethoxy)benzo[d]oxazol-5-yl)ethanone Hydrochloride |
| SMILES | C1(OCCN2CCCCC2)C(OCCC(C)C2C=CC(F)=CC=2)=C2OC(C)=NC2=C(C)C=1C(C)=O.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C28H35FN2O4.ClH/c1-18(22-8-10-23(29)11-9-22)12-16-33-28-26(34-17-15-31-13-6-5-7-14-31)24(20(3)32)19(2)25-27(28)35-21(4)30-25;/h8-11,18H,5-7,12-17H2,1-4H3;1H |
| InChiKey | FHCGCBIHIRQNML-UHFFFAOYSA-N |
| CID | 91826479 |
| Short Description | K+ channel blocker |
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