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(±)-BMS 204352
- Soluble in DMSO
- MF: C16H10ClF4NO2
- MW: 359.7
Description
(±)-BMS 204352 is the racemic form of BMS 204352 (Axon 1112), a potassium channel opener that activates large-conductance Ca2+-activated K+ (BK/KCa1.1, Maxi-K) channels.
BK channel activation hyperpolarizes cells and regulates neuronal excitability, smooth muscle tone and neuroprotective responses. The racemate contains the more active S-(+)-enantiomer and the less active R-(-)-enantiomer.
Key Features
- Racemate of the BK channel opener BMS 204352
- Activates KCa1.1/Maxi-K potassium channels
- Contains active S-(+) and less active R-(-) enantiomers
- Useful for potassium channel opener pharmacology
Applications
- BK/KCa1.1 channel assays
- Neuronal excitability and hyperpolarization studies
- Stroke and neuroprotection model research
- Enantiomer comparison studies
The S-(+)-enantiomer BMS-204352/Flindokalner (Axon 1112) and R-(-)-enantiomer (Axon 1309) are available for comparative studies.
More Information
| Parent CAS No. | 183720-28-7 |
|---|---|
| Chemical Name | 3-(5-Chloro-2-methoxy-phenyl)-3-fluoro-6-trifluoromethyl-1,3-dihydro-indol-2-one |
| SMILES | C1(=O)NC2C=C(C(F)(F)F)C=CC=2C1(F)C1C=C(Cl)C=CC=1OC |
| MFCD | MFCD00952750 |
| InChi | InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23) |
| InChiKey | ULYONBAOIMCNEH-UHFFFAOYSA-N |
| CID | 9885204 |
| Short Description | K+ channel opener |
References
- Krishna R et al. Pharmacokinetics and dose proportionality of BMS-204352 after intraarterial administration to rats. Biopharm Drug Dispos. 2002, 23(6), 233-7.
- M. P. G. Korsgaard et al. Anxiolytic Effects of Maxipost (BMS-204352) and Retigabine via Activation of Neuronal Kv7 Channels. J. Pharmacol. Exp. Ther. 2005, 314, 282-292.
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