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Flupirtine maleate
- D 9998 - Katadolon
- Parent CAS: 56995-20-1
- Soluble in DMSO
- MF: C15H17FN4O2.C4H4O4
- MW: 420.39
Description
Flupirtine maleate is a centrally acting, non-opioid analgesic that activates neuronal Kv7/KCNQ potassium channels, stabilizing membrane potential and reducing excitability.
Flupirtine can indirectly reduce NMDA receptor-driven excitotoxicity by limiting depolarization and calcium entry. It is used in studies of Kv7 channel opening, analgesia, neuronal excitability and cytoprotection.
Key Features
- Neuronal Kv7/KCNQ potassium-channel opener
- Reduces membrane excitability and repetitive firing
- Centrally acting non-opioid analgesic pharmacology
- Indirectly limits excitotoxic NMDA receptor activation
Applications
- Kv7 channel electrophysiology
- Neuronal excitability and membrane-potential studies
- Analgesia and nociception models
- Excitotoxicity and neuroprotection research
More Information
| Parent CAS No. | 56995-20-1 |
|---|---|
| Chemical Name | [2-Amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester maleate |
| SMILES | C1(N)N=C(NCC2C=CC(F)=CC=2)C=CC=1NC(OCC)=O.C(=C/C(O)=O)/C(=O)O |
| MFCD | MFCD00941415 |
| InChi | InChI=1S/C15H17FN4O2.C4H4O4/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10;5-3(6)1-2-4(7)8/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChiKey | DPYIXBFZUMCMJM-BTJKTKAUSA-N |
| CID | 6435335 |
| Short Description | Analgesic |
References
- MD Swedberg et al. Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat. J. Pharmacol. Exp. Ther. 1988, 246(3), 1067–74.
- S Dhar et al. Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. Ann. Neurol. 2002, 51 (4), 448–66.
- G. Schuster et al. Flupirtine: A Review of Its Neuroprotective and Behavioral Properties. CNS Drug Reviews, 1998, 4(2), 149-164.
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