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CP 945598
- Otenabant
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C25H25Cl2N7O
- MW: 510.42
Description
Potent and selective cannabinoid CB1 receptor antagonist (Ki values 0.7 nM and 0.2 nM in binding and functional assays, respectively) for the management of obesity. CP945598 exhibits a >10000 fold selectivity over CB2, and lacks significant, or meaningful, activity at a large panel of receptors, enzymes, and ion channels. Available as HCl salt as well (Axon 2119)
More Information
| Parent CAS No. | 686344-29-6 |
|---|---|
| Chemical Name | 1-(8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide |
| extra_info | . |
| SMILES | N1(C2=C3C(=NC=N2)N(C2=CC=C(Cl)C=C2)C(C2=CC=CC=C2Cl)=N3)CCC(NCC)(C(N)=O)CC1 |
| MFCD | MFCD11973672 |
| InChi | InChI=1S/C25H25Cl2N7O/c1-2-31-25(24(28)35)11-13-33(14-12-25)22-20-23(30-15-29-22)34(17-9-7-16(26)8-10-17)21(32-20)18-5-3-4-6-19(18)27/h3-10,15,31H,2,11-14H2,1H3,(H2,28,35) |
| InChiKey | UNAZAADNBYXMIV-UHFFFAOYSA-N |
| CID | 10052040 |
| Short Description | CB1 antagonist |
References
- J.R. Hadcock et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB(1) receptor antagonist for the management of obesity. Biochem Biophys Res Commun. 2010 Apr 2;394(2):366-71.
- L.J. Aronne et al. Efficacy and safety of CP-945,598, a selective cannabinoid CB1 receptor antagonist, on weight loss and maintenance. Obesity (Silver Spring). 2011 Jul;19(7):1404-14.
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