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SR 141716 hydrochloride
- Rimonabant hydrochloride
- Parent CAS: 168273-06-1
- Soluble in DMSO and EtOH
- MF: C22H21Cl3N4O.HCl
- MW: 500.25
Description
SR 141716 hydrochloride (Rimonabant) is a potent, selective and orally active cannabinoid CB1 receptor antagonist/inverse agonist with a reported Ki value of 2 nM.
CB1 receptor signaling is central to endocannabinoid control of appetite, reward, pain perception, gastrointestinal motility and metabolic regulation. SR 141716 is a reference compound for studying CB1 pharmacology and endocannabinoid pathway blockade.
Key Features
- Potent CB1 receptor antagonist/inverse agonist
- Reported Ki: 2 nM
- Orally active with long-lasting pharmacological effects
- Reference tool for endocannabinoid pathway inhibition
Applications
- CB1 receptor pharmacology
- Endocannabinoid signaling studies
- Food intake and metabolism models
- Gastrointestinal motility and cannabinoid response assays
More Information
| Parent CAS No. | 168273-06-1 |
|---|---|
| Chemical Name | 5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide hydrochloride |
| SMILES | C1(C2=CC=C(Cl)C=C2)=C(C)C(C(NN2CCCCC2)=O)=NN1C1C(Cl)=CC(Cl)=CC=1.Cl |
| MFCD | MFCD04034714 |
| InChi | InChI=1S/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H |
| InChiKey | REOYOKXLUFHOBV-UHFFFAOYSA-N |
| CID | 104849 |
| Short Description | CB1 antagonist |
References
- J Simiand et al. SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Behav. Pharmacol. 1998, 9(2), 179-81.
- M Rinaldi-Carmona et al. Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist. Life Sci. 1995;56(23-24):1941-7.
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