Bulk Inquiry
DBPR211
- Soluble in DMSO
- MF: C33H31Cl2F3N6O3S2
- MW: 751.67
Description
DBPR211 is a potent and selective peripherally restricted CB1 antagonist and/or inverse agonist (Ki value of 0.3 nM). DBPR211 shows significant weight-loss efficacy in diet-induced obese mice.
More Information
| Parent CAS No. | 1429239-98-4 |
|---|---|
| Chemical Name | 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide |
| SMILES | C1(N2C(C3SC(C#CC4C=CC(C(F)(F)F)=CC=4)=CC=3)=C(CNS(N3CCCC3)(=O)=O)C(C(=O)NN3CCCCC3)=N2)C(Cl)=CC(Cl)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C33H31Cl2F3N6O3S2/c34-24-11-14-28(27(35)20-24)44-31(29-15-13-25(48-29)12-8-22-6-9-23(10-7-22)33(36,37)38)26(21-39-49(46,47)43-18-4-5-19-43)30(40-44)32(45)41-42-16-2-1-3-17-42/h6-7,9-11,13-15,20,39H,1-5,16-19,21H2,(H,41,45) |
| InChiKey | KAIYFJUWIBTYPK-UHFFFAOYSA-N |
| CID | 71515460 |
| Short Description | CB1 antagonist |
References
- CP Chang et al. Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist. Bioorg Med Chem. 2019 Jan 1;27(1):216-223.
- CP Chang et al. Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice. J Med Chem. 2013 Dec 27;56(24):9920-33.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1218 | AM 251 |
From $104.50 |
| 1219 | AM 281 |
From $104.50 |
| 1220 | SR 141716 hydrochloride |
From $77.00 |
| 1550 | MK 0364 |
From $104.50 |
| 1565 | PSNCBAM 1 |
From $93.50 |
| 1712 | rac-(±)-SLV 319 |
From $121.00 |
| 1713 | SLV 319 |
From $115.50 |
| 1714 | (R)-(+)-SLV 319 |
From $104.50 |
| 1925 | GW 842166X |
From $121.00 |
| 2015 | CP 945598 |
From $148.50 |
| 2119 | CP 945598 hydrochloride |
From $148.50 |
| 2543 | ZCZ 011 |
From $99.00 |
| 2791 | AM 4113 |
From $115.50 |
| 3632 | Genistein |
From $77.00 |
| 4309 | GAT211 |
From $99.00 |
| 4358 | GAT228 |
From $110.00 |
| 4359 | GAT229 |
From $121.00 |
