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SLV 319
- Ibipinabant - (S)-(-)-SLV 319
- Optical Purity: >98% e.e.
- Soluble in DMSO
- MF: C23H20Cl2N4O2S
- MW: 487.4
Description
SLV 319 is a potent and highly selective cannabinoid CB1 receptor antagonist with Ki values of 7.8 nM for CB1 and 7943 nM for CB2.
CB1 receptors regulate appetite, reward, pain and metabolic signaling through the endocannabinoid system. SLV 319 is useful for studying CB1-selective antagonism and differentiating central CB1 pharmacology from peripheral CB2 activity.
Key Features
- Potent CB1 receptor antagonist
- Ki: 7.8 nM for CB1 and 7943 nM for CB2
- Approximately 100-fold more potent S-enantiomer versus the R-enantiomer
- Selective tool for endocannabinoid receptor studies
Applications
- CB1 receptor pharmacology
- Endocannabinoid signaling research
- Metabolic and appetite regulation models
- GPCR antagonist selectivity assays
Note: The opposite R(+)-SLV319 enantiomer is available as Axon 1714.
More Information
| Parent CAS No. | 464213-10-3 |
|---|---|
| Chemical Name | (S)-(-)-3-(4-chlorophenyl)-N'-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide |
| SMILES | C1(S(=O)(=O)/N=C(N2N=C(C3C=CC(Cl)=CC=3)[C@@H](C3C=CC=CC=3)C2)/NC)C=CC(Cl)=CC=1 |&1:16,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28)/t21-/m1/s1 |
| InChiKey | AXJQVVLKUYCICH-OAQYLSRUSA-N |
| CID | 9826744 |
| Short Description | CB1 antagonist |
References
- JH Lange etal. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J. Med.l Chem. 2004, 47(3), 627–643.
- JH Lange and CG Kruse. Recent advances in CB1 cannabinoid receptor antagonists. Curr. Opin. Drug Discov. Devel. 2004, 7(4), 498-506.
- AB Need et al. The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats. Psychopharmacol. 2006, 184(1), 26–35.
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