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AM630
- 6-Iodopravadoline
- Soluble in DMSO
- MF: C23H25IN2O3
- MW: 504.36
Description
AM630 (6-Iodopravadoline) is a selective cannabinoid CB2 receptor antagonist/inverse agonist used to block CB2-mediated endocannabinoid signaling.
CB2 receptors are enriched in immune and inflammatory contexts and regulate cytokine release, immune-cell function and tissue responses. AM630 is a standard tool for studying CB2 receptor pharmacology and distinguishing CB2-dependent effects from CB1 signaling.
Key Features
- Selective CB2 receptor antagonist/inverse agonist
- Blocks immune-associated cannabinoid signaling
- Useful for separating CB2- from CB1-mediated responses
- Reference antagonist for endocannabinoid pathway studies
Applications
- CB2 receptor pharmacology
- Inflammation and immune signaling research
- Cannabinoid receptor selectivity assays
- Endocannabinoid pathway modulation studies
More Information
| Parent CAS No. | 164178-33-0 |
|---|---|
| Chemical Name | [6-Iodo-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-(4-methoxy-phenyl)-methanone |
| SMILES | C1(I)C=C2N(CCN3CCOCC3)C(C)=C(C(C3C=CC(OC)=CC=3)=O)C2=CC=1 |
| MFCD | MFCD01861183 |
| InChi | InChI=1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3 |
| InChiKey | JHOTYHDSLIUKCJ-UHFFFAOYSA-N |
| CID | 4302963 |
| Short Description | CB2 antagonist |
References
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