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NN414
- Tifenazoxide
- Soluble in DMSO
- MF: C9H10ClN3O2S2
- MW: 291.78
Description
NN414 is a potent and Kir6.2/SUR1-selective ATP-sensitive potassium (KATP) channel opener that suppresses glucose-stimulated insulin release in vitro and in vivo.
By stabilizing beta-cell KATP channel activity, NN414 is relevant for studies of membrane excitability, insulin granule secretion, pancreatic beta-cell physiology and pharmacological control of glucose homeostasis.
Key Features
- Selective opener of Kir6.2/SUR1 KATP channels
- Inhibits glucose-stimulated insulin secretion
- Modulates beta-cell membrane excitability
- Useful tool for pancreatic KATP channel pharmacology
Applications
- Insulin secretion and beta-cell function studies
- KATP channel assay development
- Glucose homeostasis and diabetes-related research
- Ion channel pharmacology in endocrine models
More Information
| Parent CAS No. | 279215-43-9 |
|---|---|
| Chemical Name | 6-Chloro-3-(1-methylcyclopropylamino)-4H-thieno[3,2-e][1,2,4]thiadiazine-1,1-dioxide |
| SMILES | O=S1(N=C(NC2(CC2)C)NC2C=C(Cl)SC1=2)=O |
| MFCD | MFCD18711369 |
| InChi | InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13) |
| InChiKey | KYSFUHHFTIGRJN-UHFFFAOYSA-N |
| CID | 135410911 |
| Short Description | KATP channel opener |
References
- RD Carr et al. NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat. Diabetes 2003, 52(10), 2513-2518.
- M Zdravkovic et al. The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener, in healthy male subjects. J. Clin. Pharmacol. 2005, 45(7), 763-772.
- JB Hansen. Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives. Curr. Med. Chem. 2006, 13(4), 361-76.
- M Zdravkovic et al. The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener in subjects with type 2 diabetes. Exp. Clin. Endocrinol Diabetes. 2007, 115(6), 405-406.
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