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Zatebradine hydrochloride
- UL-FS 49
- Parent CAS: 85175-67-3
- Soluble in water and DMSO
- MF: C26H36N2O5.HCl
- MW: 493.04
Description
Zatebradine hydrochloride is an HCN channel blocker that inhibits neuronal Ih currents, cardiac If pacemaker currents and related ATP-sensitive Kir channel activity.
HCN channels regulate neuronal excitability, rhythmic firing and cardiac pacemaker activity. Zatebradine is used as a bradycardic and electrophysiology tool compound for studying Ih/If current contributions to excitability.
Key Features
- Blocks HCN-mediated Ih and If currents
- Inhibits cardiac pacemaker current and neuronal Ih
- Specific bradycardic pharmacology profile
- Useful for electrophysiology and excitability studies
Applications
- HCN channel electrophysiology
- Cardiac If current research
- Neuronal excitability and rhythmic firing studies
- Bradycardic agent pharmacology
More Information
| Parent CAS No. | 85175-67-3 |
|---|---|
| Chemical Name | 3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one hydrochloride |
| SMILES | C1(OC)C=C2CCN(CCCN(C)CCC3C=C(OC)C(OC)=CC=3)C(=O)CC2=CC=1OC.Cl |
| MFCD | MFCD06798356 |
| InChi | InChI=1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H |
| InChiKey | ZRNKXJHEQKMWCH-UHFFFAOYSA-N |
| CID | 3045335 |
| Short Description | HCN channel blocker |
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