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BMS 204352
- Flindokalner - (S)-(+)-BMS 204352 - MaxiPost
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C16H10ClF4NO2
- MW: 359.7
Description
Maxi-K channel opener, potential therapeutic for the treatment of stroke; more active S-(+)-enantiomer in comparison with R-(-)-enantiomer (Axon 1309)
More Information
| Parent CAS No. | 187523-35-9 |
|---|---|
| Chemical Name | (S)-3-(5-Chloro-2-methoxy-phenyl)-3-fluoro-6-trifluoromethyl-1,3-dihydro-indol-2-one |
| SMILES | C1(=O)NC2C=C(C(F)(F)F)C=CC=2[C@]1(F)C1C=C(Cl)C=CC=1OC |&1:13,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1 |
| InChiKey | ULYONBAOIMCNEH-HNNXBMFYSA-N |
| CID | 214350 |
| Short Description | K+ channel opener |
References
- R Krishna et al. Pharmacokinetics and dose proportionality of BMS-204352 after intraarterial administration to rats. Biopharm. Drug Dispos. 2002, 23(6), 233-7.
- MPG Korsgaard et al. Anxiolytic Effects of Maxipost (BMS-204352) and Retigabine via Activation of Neuronal Kv7 Channels. J. Pharmacol. Exp. Ther.2005, 314, 282-292.
- YK Son et al. The inhibitory effect of Ca2+-activated K+ channel activator, BMS on L-type Ca2+ channels in rat ventricular myocytes. Life sciences, 2011, 89(9), 331-336. (*BMS204352 used in this study is procured from Axon Medchem.)
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