Potassium

Potassium

A group of potassium channels with a predicted membrane topology of two TMDs (M1–M2) and a pore (P) domain comprises inward rectifier channels (Kir) and ATP-sensitive (KATP) channels. Currently, seven subfamilies (Kir1–7) have been identified, the majority of which form K+ channels with varying degrees of inward rectification when expressed in heterologous expression systems. They can be classified into four functional groups: classical Kir channels (Kir2.x) are constitutively active, G protein-gated Kir channels (KG or Kir3.x) are regulated by G protein-coupled receptors, ATP-sensitive K+ channels (Kir6.x) are tightly linked to cellular metabolism, and K+ transport channels (Kir1.x, Kir4.x, Kir5.x, and Kir7.x) .

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More About Potassium

A group of potassium channels with a predicted membrane topology of two TMDs (M1–M2) and a pore (P) domain comprises inward rectifier channels (Kir) and ATP-sensitive (KATP) channels. Currently, seven subfamilies (Kir1–7) have been identified, the majority of which form K+ channels with varying degrees of inward rectification when expressed in heterologous expression systems. They can be classified into four functional groups: classical Kir channels (Kir2.x) are constitutively active, G protein-gated Kir channels (KG or Kir3.x) are regulated by G protein-coupled receptors, ATP-sensitive K+ channels (Kir6.x) are tightly linked to cellular metabolism, and K+ transport channels (Kir1.x, Kir4.x, Kir5.x, and Kir7.x) [1].

[1] H. Hibino et al. Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev. 2010 Jan;90(1):291-366.

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