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VU0468554
Axon 3593
CAS:
1448705-21-2
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C20H22N4O
- MW: 334.41
Description
VU0468554 is a selective GIRK inhibitor with IC50 values of 0.85 μM and 2.6 μM for GIRK1/GIRK4 and GIRK1/GIRK2 channels, respectively. VU0468554 more effectively inhibits the cardiac GIRK channel than the neuronal GIRK channel.
More Information
| Parent CAS No. | 1448705-21-2 |
|---|---|
| Chemical Name | 1-(3-Isopropyl-1-phenyl-1H-pyrazol-5-yl)-3-m-tolylurea |
| SMILES | C1C=CC(NC(=O)NC2=CC(C(C)C)=NN2C2C=CC=CC=2)=CC=1C |
| MFCD | N.A. |
| InChi | InChI=1S/C20H22N4O/c1-14(2)18-13-19(24(23-18)17-10-5-4-6-11-17)22-20(25)21-16-9-7-8-15(3)12-16/h4-14H,1-3H3,(H2,21,22,25) |
| InChiKey | AMCGZCKPUGVFCK-UHFFFAOYSA-N |
| CID | 71812793 |
| Short Description | GIRK inhibitor |
References
- A Anderson et al. Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein-Gated Inwardly Rectifying K+ Channels. Mol Pharmacol. 2021 Dec;100(6):540-547.
- W Wen et al. Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4562-6.
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