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Glipizide
Axon 3503
CAS:
29094-61-9
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C21H27N5O4S
- MW: 445.54
Description
Antidiabetic; KATP channel blocker; the drug inhibits the sulfonylurea receptor 1 (SUR1), the regulatory subunit of the ATP-sensitive potassium channels (KATP) in pancreatic β cells.
More Information
| Parent CAS No. | 29094-61-9 |
|---|---|
| Chemical Name | N-(4-(N-(Cyclohexylcarbamoyl)sulfamoyl)phenethyl)-5-methylpyrazine-2-carboxamide |
| SMILES | C1(C)N=CC(C(=O)NCCC2C=CC(S(=O)(=O)NC(NC3CCCCC3)=O)=CC=2)=NC=1 |
| MFCD | MFCD00072159 |
| InChi | InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28) |
| InChiKey | ZJJXGWJIGJFDTL-UHFFFAOYSA-N |
| CID | 3478 |
| Short Description | KATP channel blocker |
References
- RN Brogden et al. Glipizide: a review of its pharmacological properties and therapeutic use. Drugs. 1979 Nov;18(5):329-53.
- LH Bösenberg et al. The mechanism of action of oral antidiabetic drugs: A review of recent literature. Journal of Endocrinology, Metabolism and Diabetes of South Africa, 2008; 13:3, 80-88.
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