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K+ Channel inhibitor 1734
Axon 1734
CAS:
343240-54-0
Purity:
97%
- Soluble in DMSO and EtOH
- MF: C15H13Cl2N3O2
- MW: 338.19
Description
Building block for synthesis of dihydropyrazolopyrimidine inhibitors of Kv1.5 (IKur). The ethylester analog of inhibitor 1734 is a modest inhibitor itself (IC50 value 1.1 µM for human Kv1.5), but exhibiting encouraging KV1.5 versus L-type calcium channel selectivity.
More Information
| Parent CAS No. | 343240-54-0 |
|---|---|
| Chemical Name | methyl 7-(2,3-dichlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate |
| SMILES | C1(C(=O)OC)C(C2C=CC=C(Cl)C=2Cl)N2N=CC=C2NC=1C |
| MFCD | N.A. |
| InChi | InChI=1S/C15H13Cl2N3O2/c1-8-12(15(21)22-2)14(20-11(19-8)6-7-18-20)9-4-3-5-10(16)13(9)17/h3-7,14,19H,1-2H3 |
| InChiKey | FFVXEFSTAAFKEN-UHFFFAOYSA-N |
| CID | 135486149 |
| Short Description | Building Block |
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