Bulk Inquiry
(R)-(-)-BMS 204352
- Optical Purity: >98% e.e.
- Soluble in DMSO
- MF: C16H10ClF4NO2
- MW: 359.7
Description
(R)-(-)-BMS 204352 is the less active R-(-)-enantiomer of BMS 204352, a Maxi-K/BK potassium channel opener.
Enantiomer-resolved BMS 204352 compounds support stereoselective analysis of BK channel activation, neuronal excitability and neuroprotective pharmacology. (R)-(-)-BMS 204352 is useful as a lower-activity comparator to the S-(+)-enantiomer.
Key Features
- Less active R-(-)-enantiomer of BMS 204352
- Comparator for BK/KCa1.1 channel opener studies
- Supports stereoselective potassium channel pharmacology
- Relevant to neuronal excitability and neuroprotection research
Applications
- BK channel pharmacology comparisons
- Enantiomer selectivity studies
- Potassium channel opener profiling
- Neuronal excitability models
The more active S-(+)-enantiomer BMS-204352/Flindokalner (Axon 1112) is also available from Axon Medchem.
More Information
| Parent CAS No. | 187523-36-0 |
|---|---|
| Chemical Name | (R)-3-(5-Chloro-2-methoxy-phenyl)-3-fluoro-6-trifluoromethyl-1,3-dihydro-indol-2-one |
| SMILES | C1(=O)NC2C=C(C(F)(F)F)C=CC=2[C@@]1(F)C1C=C(Cl)C=CC=1OC |&1:13,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m1/s1 |
| InChiKey | ULYONBAOIMCNEH-OAHLLOKOSA-N |
| CID | 656757 |
| Short Description | K+ channel opener |
References
- Krishna R et al. Pharmacokinetics and dose proportionality of BMS-204352 after intraarterial administration to rats. Biopharm Drug Dispos. 2002, 23(6), 233-7.
- M. P. G. Korsgaard et al. Anxiolytic Effects of Maxipost (BMS-204352) and Retigabine via Activation of Neuronal Kv7 Channels. J. Pharmacol. Exp. Ther. 2005, 314, 282-292.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1112 | BMS 204352 |
From $143.00 |
| 1248 | Zatebradine hydrochloride |
From $132.00 |
| 1274 | PNU 37883 hydrochloride |
From $121.00 |
| 1294 | Chromanol 293B |
From $143.00 |
| 1305 | XE 991 dihydrochloride |
From $99.00 |
| 1308 | (±)-BMS 204352 |
From $137.50 |
| 1313 | 1-EBIO |
From $55.00 |
| 1322 | DMP 543 |
From $99.00 |
| 1437 | Flupirtine maleate |
From $71.50 |
| 1525 | Retigabine |
From $99.00 |
| 1647 | NN414 |
From $132.00 |
| 1657 | S 9947 |
From $137.50 |
| 1735 | Kv1.3 Channel blocker 42 |
From $121.00 |
| 1757 | HMR 1098 |
From $104.50 |
| 1987 | XE 991 |
From $99.00 |
| 2064 | Glibenclamide potassium salt |
From $55.00 |
| 2094 | NS 6180 |
From $99.00 |
| 2103 | Dofetilide |
From $93.50 |
| 2243 | AVE 0118 hydrochloride |
From $132.00 |
| 2252 | Retigabine dihydrochloride |
From $99.00 |
| 2329 | NS 19504 |
From $99.00 |
| 2403 | PK-THPP |
From $154.00 |
| 2854 | NS 1619 |
From $104.50 |
