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ML252
- Parent CAS: 1392494-64-2
- Soluble in DMSO
- MF: C20H24N2O.HCl
- MW: 344.88
Description
ML252 is a potent, selective and brain penetrant inhibitor of KCNQ2 (Kv7.2) voltage-gated potassium channel. It inhibits KCNQ2 channel with IC50 value of 69 nM and exhibits >40-fold selectivity over KCNQ1 to reduce off-target cardiotoxicity. It also shows excellent selectivity across a screen of over 68 GPCRs, ion channels, and transporters. It is a useful in vivo tool compound to study KCNQ2 pharmacology.
KCNQ2 pharmacology is relevant to disease-relevant cellular and translational research models; ML252 supports mechanistic studies of KCNQ2, KCNQ1, CNS in biochemical, cellular and disease-model assays.
Key Features
- KCNQ2 inhibitor for interrogation of KCNQ2 biology
- Kv7.2; IC50 69 nM, and >40-fold selective over KCNQ1
- Modulates KCNQ2-dependent signaling or biological activity
- A useful in vivo tool molecule to study KCNQ2 pharmacology
Applications
- KCNQ2 pharmacology and target-validation studies
- KCNQ2 pathway and signaling assays
- Disease-relevant cellular and translational model systems
- Transporter or ion-channel functional assays
More Information
| Parent CAS No. | 1392494-64-2 |
|---|---|
| Chemical Name | (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide hydrochloride |
| MFCD | N.A. |
| Short Description | KCNQ2 inhibitor |
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