The Vanilloid receptor (TRPV1), member of the Transient Receptor Potential Channel super family, is an ion channel which is selective for calcium and magnesium over sodium ions. It is believed to be activated through a variety of mechanisms, among which the binding of molecules containing a vanillyl moiety, also present in capsaicin. ABT102 (Axon 1504) does not show this particular vanillyl moiety, yet is a member of the class of di(arylalkyl)- and aryl(arylakyl)ureas, a class of compounds that also include two SB compounds (SB 705498, and SB 452533), which have entered clinical trials.
 (R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo. C.S. Surowy et al. J. Pharmacol. Exp. Ther. 2008, 326, 879–888.