TRPA1

The transient receptor potential ankyrin-repeat 1 (TRPA1) channel  is the sole member of  the TRPA branch of the TRP ion channel gene family. TRPA channels resemble TRPN channels that were implicated in mechanotransduction and hearing in Drosophila and zebrafish. However, the ion channel domain of TRPA channels is evolutionarily distant from TRPN channels[1]. TRPA1 channels are required for neuronal excitation, the release of inflammatory neuropeptides, and subsequent pain hypersensitivity[2]. TRPA1 is also activated by the release of inflammatory agents from nonneuronal cells in the area of tissue injury or disease, and by environmental irritants and pungent chemicals, such as cinnamaldehyde and mustard oil. Extracellular Ca2+ is a key regulator of TRPA1 activity, both potentiating and subsequently inactivating it[3].


[1] W.B. Liedtke, S. Heller, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press; 2007.
[2] D.M. Bautista et al. TRPA1: A gatekeeper for inflammation. Annu Rev Physiol. 2013;75:181-200.
[3] Y.Y. Wang et al. The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem. 2008 Nov 21;283(47):32691-703.

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2374 Optovin Reversible photoactivated TRPA1 agonist €85.00

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