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AM 36 dihydrochloride
- CNSB002
- Moderately soluble in water
- MF: C27H39ClN2O2.2HCl
- MW: 531.99
Description
AM 36 dihydrochloride (CNSB002) is a sodium channel blocker with neuroprotective activity. It is used to study sodium channel-dependent excitability and injury-related neuronal signaling.
Voltage-gated sodium channels are central to action potential propagation and excitotoxic injury mechanisms. AM 36 dihydrochloride is relevant for experiments assessing neuroprotection, ion channel blockade and neuronal survival under stress conditions.
Key Features
- Sodium channel blocker
- Neuroprotective research compound
- Useful for studying excitability and neuronal injury pathways
- Supports mechanism-focused pharmacology and assay development
Applications
- Sodium channel pharmacology
- Neuroprotection assays
- Excitotoxicity and injury models
- Neuronal excitability research
More Information
| Parent CAS No. | 199467-52-2 |
|---|---|
| Chemical Name | 2,6-Di-tert-butyl-4-{4-[2-(4-chloro-phenyl)-2-hydroxy-ethyl]-piperazin-1-ylmethyl}-phenol dihydrochloride |
| SMILES | C1(C(C)(C)C)C=C(CN2CCN(CC(O)C3C=CC(Cl)=CC=3)CC2)C=C(C(C)(C)C)C=1O.Cl.Cl |
| MFCD | MFCD10565919 |
| InChi | InChI=1S/C27H39ClN2O2.2ClH/c1-26(2,3)22-15-19(16-23(25(22)32)27(4,5)6)17-29-11-13-30(14-12-29)18-24(31)20-7-9-21(28)10-8-20;;/h7-10,15-16,24,31-32H,11-14,17-18H2,1-6H3;2*1H |
| InChiKey | WDXVQKZIZUKBOZ-UHFFFAOYSA-N |
| CID | 56972138 |
| Short Description | Na+ channel Blocker |
References
- J. K. Callaway et al. Delayed Treatment With AM-36, a Novel Neuroprotective Agent, Reduces Neuronal Damage After Endothelin-1–Induced Middle Cerebral Artery Occlusion in Conscious Rats. Stroke. 1999, 30, 2704-2712.
- J. K Callaway et al. Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis. Br. J. Pharmacol. 2001, 132, 1691–1698.
- A. Kolosov et al. Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain. Pain Med. 2010 Jan;11(1):106-18.
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