Bulk Inquiry
Nav1.7 blocker 52
- Compound 52
- Soluble in DMSO
- MF: C25H27F3N6O3
- MW: 516.52
Description
Nav1.7 blocker 52 is a potent, state-dependent Nav1.7 voltage-gated sodium channel blocker selective for SCN9A-containing channels.
Nav1.7 regulates nociceptor excitability and is a major target in pain pathway pharmacology. Nav1.7 blocker 52 is useful for studying sodium channel state dependence, subtype selectivity and analgesic target validation.
Key Features
- Potent state-dependent Nav1.7 blocker
- Selective for voltage-gated Nav1.7/SCN9A channels
- Shows selectivity over multiple ion channels and GPCRs
- Relevant to nociceptor excitability research
Applications
- Nav1.7 electrophysiology assays
- Pain and nociception pathway studies
- Sodium channel subtype selectivity profiling
- State-dependent ion channel pharmacology
More Information
| Parent CAS No. | 1211866-85-1 |
|---|---|
| Chemical Name | N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide |
| SMILES | C1(C)C(NC2N=CN=C(N3CCC(OCC4C=CC(OC(F)(F)F)=CC=4)CC3)N=2)=CC=CC=1NC(=O)C |
| MFCD | N.A. |
| InChi | InChI=1S/C25H27F3N6O3/c1-16-21(31-17(2)35)4-3-5-22(16)32-23-29-15-30-24(33-23)34-12-10-19(11-13-34)36-14-18-6-8-20(9-7-18)37-25(26,27)28/h3-9,15,19H,10-14H2,1-2H3,(H,31,35)(H,29,30,32,33) |
| InChiKey | QLKAFHZJICDACE-UHFFFAOYSA-N |
| CID | 53361524 |
| Short Description | Nav1.7 blocker |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1113 | AM 36 dihydrochloride |
From $159.50 |
| 1444 | Lacosamide |
From $82.50 |
| 1791 | Nav1.7 blocker 24 |
From $154.00 |
| 1899 | CNV 1014802 |
From $143.00 |
| 1915 | A 803467 |
From $104.50 |
| 2056 | XEN 907 |
From $132.00 |
| 2548 | CNV 1014802 hydrochloride |
From $137.50 |
| 3454 | Mexiletine hydrochloride |
From $55.00 |
| 3507 | Ranolazine |
From $77.00 |
| 3889 | Vinpocetine |
From $55.00 |
| 4080 | DNA binder S20 hydrochloride |
From $154.00 |
