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Nav1.7 blocker 24
- Compound 24
- Soluble in DMSO
- MF: C20H16Cl2F3N3O3
- MW: 474.26
Description
Nav1.7 blocker 24 is a potent and selective Nav1.7 voltage-gated sodium channel blocker with a Nav1.7 pIC50 value of 6.75 and Nav1.5 pIC50 below 4.48.
Nav1.7/SCN9A is a key sodium channel in nociceptor excitability and pain signaling. Nav1.7 blocker 24 is useful for studying sodium channel subtype selectivity and analgesic target validation.
Key Features
- Selective blocker of Nav1.7/SCN9A channels
- Nav1.7 pIC50: 6.75
- Nav1.5 pIC50: <4.48
- Useful for sodium channel subtype selectivity studies
Applications
- Nav1.7 electrophysiology assays
- Pain and nociception research
- Sodium channel subtype profiling
- Ion channel drug discovery models
More Information
| Parent CAS No. | 1315451-25-2 |
|---|---|
| Chemical Name | 2-(3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)acetamide |
| SMILES | C1(Cl)C(C2=NOC(C)=C2CC(=O)NCC2C=CC(OCC(F)(F)F)=NC=2)=C(Cl)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H16Cl2F3N3O3/c1-11-13(19(28-31-11)18-14(21)3-2-4-15(18)22)7-16(29)26-8-12-5-6-17(27-9-12)30-10-20(23,24)25/h2-6,9H,7-8,10H2,1H3,(H,26,29) |
| InChiKey | SOEIDCOJJGHLKZ-UHFFFAOYSA-N |
| CID | 53307604 |
| Short Description | Nav1.7 blocker |
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