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XEN 907
- Soluble in DMSO
- MF: C21H21NO4
- MW: 351.4
Description
XEN 907 is a potent and selective voltage-gated sodium channel Nav1.7 (SCN9A) blocker. It inhibits Nav1.7-dependent sodium currents involved in nociceptor excitability.
Nav1.7 is a key pain target because human SCN9A mutations alter pain perception. XEN 907 is useful for studying peripheral pain signaling, sodium channel pharmacology and nociceptor excitability mechanisms.
Key Features
- Selective Nav1.7 sodium channel blocker
- Targets SCN9A-dependent sodium currents
- Relevant to nociceptor excitability and pain research
- Useful ion-channel pharmacology tool
Applications
- Nav1.7 electrophysiology
- Pain pathway model research
- Sodium channel selectivity studies
- Nociceptor excitability assays
More Information
| Parent CAS No. | 912656-34-9 |
|---|---|
| Chemical Name | 1'-pentyl-6H-spiro[benzofuro[6,5-d][1,3]dioxole-7,3'-indolin]-2'-one |
| SMILES | C12(COC3C=C4OCOC4=CC1=3)C1=C(N(CCCCC)C2=O)C=CC=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H21NO4/c1-2-3-6-9-22-16-8-5-4-7-14(16)21(20(22)23)12-24-17-11-19-18(10-15(17)21)25-13-26-19/h4-5,7-8,10-11H,2-3,6,9,12-13H2,1H3 |
| InChiKey | PHMRUZIIERITEP-UHFFFAOYSA-N |
| CID | 11998198 |
| Short Description | Nav1.7 blocker |
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