Bulk Inquiry
CNV 1014802 hydrochloride
- GSK 1014802 HCl - GSK2 HCl - Raxatrigine HCl - BIIB 074 HCl,Vixotrigine HCl
- Parent CAS: 934240-30-9
- Soluble in water and DMSO
- MF: C18H19FN2O2.HCl
- MW: 350.82
Description
CNV 1014802 hydrochloride is the water-soluble salt form of CNV 1014802 (also known as Vixotrigine, Raxatrigine, Axon 1899), a voltage-gated sodium channel blocker developed for neuropathic pain and neuronal hyperexcitability research. It suppresses Na+ channel-dependent action potential firing and has been clinically studied for trigeminal neuralgia and related indications.
Voltage-gated sodium channels drive excitability in sensory neurons, CNS circuits and pain pathways. CNV 1014802 hydrochloride is useful for studying use-dependent sodium channel blockade, neuropathic pain mechanisms and anticonvulsant pharmacology.
Key Features
- Voltage-gated sodium channel blocker
- Potent anticonvulsant activity reported in preclinical studies
- Clinically studied for trigeminal neuralgia and neuropathic pain
- Modulates neuronal hyperexcitability
Applications
- Sodium channel pharmacology
- Neuropathic pain and trigeminal neuralgia models
- Neuronal excitability assays
- Anticonvulsant pathway research
More Information
| Parent CAS No. | 934240-30-9 |
|---|---|
| Chemical Name | (2S,5R)-5-(4-(2-fluorobenzyloxy)phenyl)pyrrolidine-2-carboxamide hydrochloride |
| MFCD | N.A. |
| Short Description | Na+ channel blocker |
References
- CH Large et al. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia. J. Pharmacol. Exp. Ther. 2011, 338(1), 100-113.
- J.M. Zakrzewska et al. Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients ith trigeminal neuralgia. Trials. 2013 Nov 23;14:402.
- A. Nardi et al. Advances in targeting voltage-gated sodium channels with small molecules. ChemMedChem. 2012 Oct;7(10):1712-40.
- C.H. Large et al. The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat. Epilepsy Res. 2009 Jul;85(1):96-106.
- JR Deuis et al. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016 Mar 17;8(3). pii: E78.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1113 | AM 36 dihydrochloride |
From $159.50 |
| 1444 | Lacosamide |
From $82.50 |
| 1780 | Nav1.7 blocker 52 |
From $176.00 |
| 1791 | Nav1.7 blocker 24 |
From $154.00 |
| 1915 | A 803467 |
From $104.50 |
| 2056 | XEN 907 |
From $132.00 |
| 2638 | LP-935509 |
From $143.00 |
| 3127 | Valproic acid sodium salt |
From $66.00 |
| 3308 | Oxcarbazepine |
From $55.00 |
| 3454 | Mexiletine hydrochloride |
From $55.00 |
| 3507 | Ranolazine |
From $77.00 |
| 3889 | Vinpocetine |
From $55.00 |
| 4080 | DNA binder S20 hydrochloride |
From $154.00 |
