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DNA binder S20 hydrochloride
- C65780
Axon 4080
- Parent CAS: 442567-76-2
Purity:
99%
- Soluble in water, DMSO and EtOH
- MF: C20H21N3O.HCl
- MW: 355.86
Description
DNA binder S20 hydrochloride is an orally bioavailable antagonist of the NaV1.7 - NaV1.9 channels. S20 effectively reduces nociceptive response in various pain models without any obvious acute toxicity or inhibition of locomotion. Moreover, S20 is a strong DNA binder.
More Information
| Parent CAS No. | 442567-76-2 |
|---|---|
| Chemical Name | 2-(2-(Diethylamino)ethyl)indeno[1,2,3-de]phthalazin-3(2H)-one hydrochloride |
| MFCD | N.A. |
| Short Description | NaV1.7/NaV1.8/NaV1.9 blocker |
References
- X Kong et al. The small molecule compound C65780 alleviates pain by stabilizing voltage-gated sodium channels in the inactivated and slowly-recovering state. Neuropharmacology. 2022 Jul 1;212:109057.
- J Xu et al. Enabling programmable dynamic DNA chemistry using small-molecule DNA binders. Nat Commun. 2023 Jul 17;14(1):4248.
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