Angiotensin (AT)

The angiotensin receptors are activated by the vasoconstricting peptide angiotensin II. They are important for the renin-angiotensin system (RAS) or the renin-angiotensin-aldosterone system (RAAS); a hormone system that regulates blood pressure and water (fluid) balance. Effects mediated by the AT2 receptor are suggested to include inhibition of cell growth, fetal tissue development, modulation of extracellular matrix, neuronal regeneration, apoptosis, cellular differentiation, and maybe vasodilatation and left ventricular hypertrophy[1].


[1] The Angiotensin II Type 2 Receptor Causes Constitutive Growth of Cardiomyocytes and Does Not Antagonize Angiotensin II Type 1 Receptor–Mediated Hypertrophy. A. Amore, M.J. Black, W.G. Thomas. Hypertension. 2005, 46, 1347-1354

6 Item(s)

per page
Axon ID Name Description From price
3104 Candesartan cilexetil Potent and highly specific AT2 receptor antagonist €50.00
3102 Losartan Non-peptide, potent and orally active angiotensin II receptor antagonist €60.00
1969 M 24 First non-peptide selective AT2 receptor agonist Inquire
1276 PD 123319 ditrifluoroacetate AT2 antagonist €95.00
3103 Telmisartan Non-peptide, highly potent and selective AT1 receptor antagonist €60.00
3106 Valsartan Potent, highly selective, and orally active AT1 antagonist €76.00

6 Item(s)

per page
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