Angiotensin (AT)

The angiotensin receptors are activated by the vasoconstricting peptide angiotensin II. They are important for the renin-angiotensin system (RAS) or the renin-angiotensin-aldosterone system (RAAS); a hormone system that regulates blood pressure and water (fluid) balance. Effects mediated by the AT2 receptor are suggested to include inhibition of cell growth, fetal tissue development, modulation of extracellular matrix, neuronal regeneration, apoptosis, cellular differentiation, and maybe vasodilatation and left ventricular hypertrophy[1].


[1] The Angiotensin II Type 2 Receptor Causes Constitutive Growth of Cardiomyocytes and Does Not Antagonize Angiotensin II Type 1 Receptor–Mediated Hypertrophy. A. Amore, M.J. Black, W.G. Thomas. Hypertension. 2005, 46, 1347-1354

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Axon ID Name Description From price
1969 M 24 First non-peptide selective AT2 receptor agonist Inquire
1276 PD 123319 ditrifluoroacetate AT2 antagonist €95.00

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