Angiotensin (AT)

The angiotensin receptors are activated by the vasoconstricting peptide angiotensin II. They are important for the renin-angiotensin system (RAS) or the renin-angiotensin-aldosterone system (RAAS); a hormone system that regulates blood pressure and water (fluid) balance. Effects mediated by the AT2 receptor are suggested to include inhibition of cell growth, fetal tissue development, modulation of extracellular matrix, neuronal regeneration, apoptosis, cellular differentiation, and maybe vasodilatation and left ventricular hypertrophy[1].

[1] The Angiotensin II Type 2 Receptor Causes Constitutive Growth of Cardiomyocytes and Does Not Antagonize Angiotensin II Type 1 Receptor–Mediated Hypertrophy. A. Amore, M.J. Black, W.G. Thomas. Hypertension. 2005, 46, 1347-1354

11 Item(s)

per page
Axon ID Name Description From price
3890 (R)-(-)-PD123319 ditrifluoroacetate (Optically pure) Opposite enantiomer of PD123319 ditrifluoroacetate €140.00
3386 AVE0991 Selective and orally active Mas receptor agonist €150.00
3363 Azilsartan Potent AT1 antagonist €60.00
3104 Candesartan cilexetil Potent and highly specific AT2 receptor antagonist €50.00
3550 Fimasartan Potent and orally active angiotensin II receptor antagonist €70.00
3102 Losartan Non-peptide, potent and orally active angiotensin II receptor antagonist €60.00
1969 M 24 First non-peptide selective AT2 receptor agonist Inquire
3105 Olmesartan Potent and selective AT1 antagonist €80.00
1276 PD123319 ditrifluoroacetate (Optically pure S-enantiomer) AT2 antagonist €130.00
3103 Telmisartan Non-peptide, highly potent and selective AT1 receptor antagonist €60.00
3106 Valsartan Potent, highly selective, and orally active AT1 antagonist €76.00

11 Item(s)

per page
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