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Azilsartan
- TAK536 - AZL
Axon 3363
CAS:
147403-03-0
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C25H20N4O5
- MW: 456.45
Description
Azilsartan is a potent angiotensin II type 1 (AT1) receptor antagonist with an IC50 value of 2.6 nM.
More Information
| Parent CAS No. | 147403-03-0 |
|---|---|
| Chemical Name | 2-Ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid |
| SMILES | C1(CN2C(OCC)=NC3C=CC=C(C(O)=O)C2=3)C=CC(C2C(C3=NOC(=O)N3)=CC=CC=2)=CC=1 |
| MFCD | MFCD00916395 |
| InChi | InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32) |
| InChiKey | KGSXMPPBFPAXLY-UHFFFAOYSA-N |
| CID | 135415867 |
| Short Description | AT1 antagonist |
References
- T Kajiya et al. Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J Hypertens. 2011 Dec;29(12):2476-83.
- M Ojima et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther. 2011 Mar;336(3):801-8.
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