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Losartan
- EX 89 - DUP 89
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C22H23ClN6O
- MW: 422.91
Description
Losartan is a potent, orally active nonpeptide angiotensin II receptor antagonist which inhibited the specific binding of labeled angiotensin II to its receptor sites in rat adrenal cortical membranes and in cultured rat smooth muscle cells with IC50 values of 19 nM and 20 nM, respectively. Antihypertensive agent.
More Information
| Parent CAS No. | 114798-26-4 |
|---|---|
| Chemical Name | (1-((2'-(1H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol |
| SMILES | C1(CN2C(CCCC)=NC(Cl)=C2CO)C=CC(C2C=CC=CC=2C2NN=NN=2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) |
| InChiKey | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
| CID | 3961 |
| Short Description | AT2 antagonist |
References
- AT Chiu et al. Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent. J Pharmacol Exp Ther. 1990 Feb;252(2):711-8.
- S Whitebread et al. Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun. 1989 Aug 30;163(1):284-91.
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