Orexin (OX)

Orexin-A and orexin-B (also known as hypocretin-1 and hypocretin-2, respectively) are neuropeptides that bind to the GPCRs (GPCR-A6 subfamily)  orexin-1 (OX1) and orexin-2 (OX2). The orexin system has been implicated in the regulation of functions such as reward seeking, feeding behavior, locomotion and physical activity, and arousal from sleep and the sleep–wake cycle. Upon receptor activation, intracellular calcium levels increase. Orexin deficiency has been linked to narcoleptic symptoms such as sudden sleep attacks and cataplexy[1].

[1] Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial. P. Hoever et al. Clin. Pharm. Ther. 2012, 91, 975-985.

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Axon ID Name Description From price
2012 EMPA Orexin type 2 (OX2) receptor antagonist €135.00
3805 MK-3697 Potent and selective Orexin receptor antagonist Inquire
2095 SB 334867 First selective orexin 1 (OX1) antagonist €90.00
2192 SB 674042 Nonpeptide OX1 selective antagonist with >100 fold selectivity over the OX2 receptor. €99.00
2744 TCS1102 Dual orexin (OX1/2) receptor antagonist €90.00

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