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SB 334867
Axon 2095
CAS:
792173-99-0
Purity:
99%
- Soluble in DMSO
- MF: C17H13N5O2
- MW: 319.32
Description
SB 334867 is the first reported selective orexin type 1 receptor (OX1R/HCRTR1) antagonist. It displays approximately 50-fold higher affinity for OX1R than OX2R.
Orexin OX1 signaling is involved in arousal, reward, feeding behavior, stress responses and drug-seeking circuits. SB 334867 is useful for studying OX1-selective neuropeptide pharmacology in CNS and behavioral models.
Key Features
- Selective OX1 receptor antagonist
- Approximately 50-fold selectivity over OX2R
- Targets orexin neuropeptide signaling
- Useful for CNS behavioral pharmacology
Applications
- OX1 receptor binding assays
- Arousal and feeding behavior studies
- Addiction and reward pathway research
- Orexin receptor antagonist profiling
More Information
| Parent CAS No. | 792173-99-0 |
|---|---|
| Chemical Name | 1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea |
| SMILES | C1C=C2N=CC=C(NC(NC3C=C4OC(C)=NC4=CC=3)=O)C2=NC=1 |
| MFCD | MFCD06411602 |
| InChi | InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23) |
| InChiKey | AKMNUCBQGHFICM-UHFFFAOYSA-N |
| CID | 6604926 |
| Short Description | OX1 antagonist |
SB 334867
selective OX1 receptor antagonist
HCRTR1
OX1 receptor
Antagonist
OX1 receptor binding assays
Arousal and feeding behavior studies
Addiction and reward pathway research
Orexin receptor antagonist profiling
behavioral neuroscience
addiction research
GPCR pharmacology
receptor selectivity
signal transduction
receptor pharmacology
CNS
Axon Medchem
Axon 2095
Supplier
Vendor
References
- D Smart et al. SB‐334867‐A: the first selective orexin‐1 receptor antagonist. Br. J. Pharmacol. 2001, 132(6), 1179-1182.
- RJ Rodgers et al. SB‐334867, a selective orexin‐1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin‐A in rats. Eur. J. Neurosci. 2001, 13(7), 1444-1452.
- TE Scammell and CJ Winrow. Orexin Receptors: Pharmacology and Therapeutic Opportunities. Ann. Rev. Pharmacol. Toxicol. 2011. 51, 243–266.
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